Enantioselective annulation of enals with 2-naphthols by triazolium salts derived from l-phenylalanine.
نویسندگان
چکیده
A series of chiral triazolium salts have been synthesized from methyl l-phenylalaninate hydrochloride. The NHCs derived from this class of novel triazolium salts were found to be highly efficient catalysts in the annulation reaction of enals and 2-naphthols. These reactions proceeded with high chemoselectivity and wide substrate scope affording enantioenriched β-arylsplitomicins in good yields with up to 96% ee.
منابع مشابه
Enantioselective annulation of enals with 2-naphthols by triazolium salts derived from l-phenylalanine† †Electronic supplementary information (ESI) available: CCDC 1051429 and 1051473. For ESI and crystallographic data in CIF or other electronic format see DOI: 10.1039/c5sc00731c
A series of chiral triazolium salts have been synthesized from methyl L-phenylalaninate hydrochloride. The NHCs derived from this class of novel triazolium salts were found to be highly efficient catalysts in the annulation reaction of enals and 2-naphthols. These reactions proceeded with high chemoselectivity and wide substrate scope affording enantioenriched b-arylsplitomicins in good yields ...
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ورودعنوان ژورنال:
- Chemical science
دوره 6 7 شماره
صفحات -
تاریخ انتشار 2015